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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 1
BKCSDE 28(1)
January 20, 2007 

Synthesis and Characterization of Degradable Polycationic Polymers as Gene Delivery Carriers
Hyun Jin Kim, Min Sung Kwon, Joon Sig Choi, Bo Hye Kim, Jae Keun Yoon, Kwan Kim, Jong-sang Park*
Gene therapy, Gene delivery, Biodegradable polymer
Biodegradable cationic poly(ester-amide) polymers were synthesized by double-monomer method, that showed excellent solubility in many organic solvents and water. Different degradation patterns were obtained by the regulation of monomer ratios and overall long period of time of DNA protection up to 12 days was shown by PicoGreen reagent assay. Good transfection profiles in the presence of serum and very low toxicity on mammalian cells may allow these polymers to become suitable for long-term gene delivery systems and therapeutic applications.
63 - 67
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