Current time in Korea 11:56 Apr 26 (Fri) Year 2024 KCS KCS Publications
KCS Publications
My Journal  Log In  Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 9
BKCSDE 27(9)
September 20, 2006 
 
Title
 Synthesis and Anion Binding Affinities of Novel Molecular Tweezers Based on Chenodeoxycholic Acid Bearing Different Lengths of Arm
Author
 Ki Soo Kim, Hyun-Seok Jang, Hong-Seok Kim*
Keywords
 Anion recognition, Molecular tweezer, Chenodeoxycholic acid, Fluoride ion
Abstract
 Molecular tweezers based on chenodeoxycholic acid bearing different lengths of arm were synthesized and their anion binding affinities were evaluated by 1H NMR, isothermal calorimetric titration, and ESI mass spectrometry. Molecular tweezer 6 showed a high selectivity toward H2PO4- over Cl-, Br-, I-, and CH3CO2- by 1H NMR titration, whereas the association constant for F- revealed the largest value as determined by ITC. The selectivity of 6 towards F- was about 103 times higher than that of Cl-, H2PO4-, and CH3CO2-. ITC experiment of 6 with F- in a DMSO showed two binding modes; two sequential association constants K1 = 2.77 × 105 M-1 and K2 = 8.68 × 106 M-1 were found. These sequential bindings were confirmed by ESI mass spectrometry. 1 : 1 and 1 : 2 complexes of 6 and F- were found at m/z 868.08 and 884.04.
Page
 1445 - 1449
Full Text
 PDF

How to access to the WOL for The Bulletin of the Korean Chemical Society ?

The Bulletin of the Korean Chemical Society will be co-published with Wiley-VCH from 2015 towards. The online version of the Journal will thus be available on Wiley Online Library, Wiley(-VCH)'s global online platform.

KCS members can get a free online access to the Bulletin of the Korean Chemical Society in WOL.

Close