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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 9
BKCSDE 27(9)
September 20, 2006

Title	Synthesis of New Anthracycline Derivatives Containing Lactic or Stearic Acid Moiety
Author	Young S. Rho, Wan-Joong Kim, Dong Jin Yoo*
Keywords	Daunomycin, Doxorubicin, Anthracycline derivatives, Lactic acid, Stearic acid
Abstract	logues 2-9 as potential anticancer agents were synthesized from daunomycin (1a) and doxorubicin (1b). Compounds 2, 6, and 7 were prepared by the nucleophilic displacement type esterification of a 14-bromodaunomycin (1c) with a sodium lactate, and stearic acid, respectively. Compounds 3-5 and 7-9 were prepared by the reaction of either daunomycin (1a) or doxorubicin (1b) with L-lactic and stearic acids in the presence of EDCI/PP reagents.
Page	1359 - 1363
Full Text	PDF

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