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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 6
BKCSDE 27(6)
June 20, 2006 

Asymmetric Michael Reaction of Malonate Derivatives with α,β-Unsaturated Ketones Using Chiral Quaternary Ammonium Salts
Min Je Cho, Myoung Gi Cho, Sun Chul Huh, Sung Min Kim, Kilsung Lee, Kwang Oh Koh, Joo Yang Mang, Dae Young Kim*
Phase-transfer catalyst, Michael reactions, Asymmetric reactions, Malonates, Fluoromalonates
The catalytic enantioselective Michael reaction promoted by quaternary ammonium salts from Cinchona alkaloids as a phase-transfer catalyst is described. Treatment of malonates with α,β-unsaturated ketones under mild reaction conditions afforded the corresponding Michael adducts in good yields with good to moderate enantiomeric excesses.
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