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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 5
BKCSDE 27(5)
May 20, 2006

Title	Carnosine and Related Compounds Protect against the Hydrogen Peroxide-Mediated Cytochrome c Modification
Author	Jung Hoon Kang
Keywords	Cytochrome c, Oligomerization, Free radical scavenger, Carnosine
Abstract	Carnosine, homocarnosine and anserine might act as anti-oxidants and free radical scavengers in vivo. In the present study, the protective effects of carnosine and related compounds on the H₂O₂-mediated cytochrome c modification were studied. Carnosine, homocarnosine and anserine significantly inhibited the oligomerization of cytchrome c induced by H₂O₂. All three compounds also inhibited the formation of carbonyl compound and dityrosine during the incubation of cytochrome c with H₂O₂. These compounds effectively inhibited the peroxidase activity in the cytchrome c treated with H₂O₂. The results suggested that carnosine, homocarnosine, and anserine might protect cytochrome c against H₂O₂-mediated oxidative damage through a free radical scavenging.
Page	663 - 666
Full Text	PDF

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