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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 26, Number 8
BKCSDE 26(8)
August 20, 2005 

Aggregation of α-Synuclein Induced by Oxidized Catecholamines as a Potential Mechanism of Lewy Body
Kyung Sik Kim, Jung Hoon Kang*
Lewy body, α-Synuclein, L-DOPA, Carnosine
Lewy bodies (LBs) are neuronal inclusions that are closely related to Parkinson's disease (PD). The filamentous component of LB from patients with PD contains biochemically altered α-synuclein. We have investigated the effect of the oxidized products of catecholamines on the modification of α-synuclein. When α-synuclein was incubated with the oxidized 3,4-dihydroxyphenylalanine (L-DOPA) or dopamine, the protein was induced to be aggregated. The oxidized catecholamine-mediated α-synuclein aggregation was enhanced by copper ion. Radical scavengers, azide and N-acetyl cysteine significantly prevented the oxidized catecholamine-mediated α-synuclein aggregation. The results suggest that free radical may play a role in α-synuclein aggregation. Exposure of α-synuclein to the oxidized products of catecholamines led to the formation of dityrosine. Antioxidant dipeptides carnosine, homocarnosine and anserine significantly protected α-synuclein from the aggregation induced by the oxidized products of catecholamines.
1255 - 1259
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