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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 26, Number 3
BKCSDE 26(3)
March 20, 2005

Title	Tsaokoarylone, a Cytotoxic Diarylheptanoid from Amomum tsao-ko Fruits
Author	Surk-Sik Moon*, Soon-Chang Cho, Ji-Young Lee
Keywords	Amomum tsao-ko, Tsaokoarylone, Cytotoxicity, Curcumin, Diarylheptanoid
Abstract	The crude methanol extract of the fruits of Amomum tsao-ko (Zingiberaceae) showed cytotoxic activity. Bioactivity-guided separation led to the isolation of a diarylheptanoid, tsaokoarylone [7-(4-hydroxy-3- methoxyphenyl)-1-(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one] (2). 2 showed cytotoxicity at 4.9 and 11.4 μg/ mL (IC50) against human nonsmall cell lung cancer A549 and human melanoma SK-Mel-2, respectively, determined by SRB colorimetric method. During purification 6-(4-hydroxyphenyl)-4-hydroxyhexan-2-one (4) together with three known diarylheptanoids was also isolated. Their structures were determined from interpretation of spectroscopic data (IR, UV, MS, and NMR) and synthesis confirmed the structure of 2.
Page	447 - 450
Full Text	PDF

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