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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 8
BKCSDE 25(8)
August 20, 2004 

 
Title
Metabolic Stability of [18F]Fluoroalkylbiphenyls
Author
Kyo Chul Lee, Sang-Yoon Lee, Yearn Seong Choe, Dae Yoon Chi*
Keywords
Metabolism study, Fluoroalkyl, Fluoroalkylaromatics, Fluorine-18, PET tracer
Abstract
The stability of fluoroalkyl groups as a pendent on the phenyl ring was measured in vitro using rat hepatic microsomes and human serum to predict their in vivo stabilities. We have prepared three [18F]fluoroalkylbiphenyls as the model compounds of fluoroalkyl aromatic compounds to compare the in vitro stabilities. In addition, in vitro stabilities were measured separately using rat hepatic microsomes and human serum at 37 oC. Fluoroethylbiphenyl had similar or slightly superior stability to fluoropropylbiphenyl and these two compounds were much more stable than fluoromethylbiphenyl in vitro.
Page
1225 - 1230
Full Text
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