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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 23, Number 7
BKCSDE 23(7)
July 20, 2002 

Design, Syntheses and Biological Evaluations of Nonpeptidic Caspase 3 Inhibitors
Eun-sook Kim, Sung-eun Yoo, Kyu Yang Yi, Sunkyung Lee, Jae-sung Noh,Yong-Sam Jung,Eunhee Kim, Nakcheol Jeong
Methylation, Naphthalene, Zeolite.
Caspase 3, a member of cysteine protease family, is well known as a major apoptosis effector and is involved in cell death as a result of ischemic diseases such as stroke and myocardial infarction, therefore the inhibition of caspase 3 may protect those apoptotic cell damages. During the high-throughput screening of the compounds from the Korea Chemical Bank, berberine derivatives (A and B), an isoquinoline alkaloid, have been identified as potential inhibitors for caspase 3. Based on this finding we carried out molecular modeling study to identify the pharmacophoric elements of berberine structure which interact with a substrate-recognition binding site of caspase 3 and came up with several novel scaffolds. In this report, we will discuss the molecular modeling, syntheses and the enzyme inhibitory activities of these novel compounds.
1003 - 1010
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