KCS Publications

HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 22, Number 11
BKCSDE 22(11)
November 20, 2001

Title	Synthesis of Water-Soluble Aminoaryloxy-Methylamino Cosubstituted Polyphosphazenes as Carrier Species for Biologically Active Agents
Author	Suk-Ky Kwon
Keywords	Aminoaryloxy, Methylamino, Polyphosphazenes.
Abstract	The water-soluble poly(aminoaryloxy-methylamino phosphazene) has been synthesized and investigated as a polymeric carrier species for the covalent attachment of biologically active agents. The cyclic trimeric model systems were utilized for the synthesis of polymeric analogues containing bioactive side groups. The sodium salt of 4-acetamidophenol was first allowed to react with (NPCl₂)₃ or (NPCl₂)_n and was then treated with excess methylamine to yield derivatives of type [NP(NHCH₃)_x(OArNHCOCH₃)_y]₃ or [NP(NHCH₃)_x(OArNHCOCH₃)_y]_n. The 4-acetamido groups were then hydrolyzed to 4-aminophenoxy units with potassium tert-butoxide. Coupling reactions between amino group and N-acetylglycine was accomplished with the use of dicyclohexylcarbodiimide. Their properties and structural characterization are discussed.
Page	1243 - 1247
Full Text	PDF

How to access to the WOL for The Bulletin of the Korean Chemical Society ?

The Bulletin of the Korean Chemical Society will be co-published with Wiley-VCH from 2015 towards. The online version of the Journal will thus be available on Wiley Online Library, Wiley(-VCH)'s global online platform.

KCS members can get a free online access to the Bulletin of the Korean Chemical Society in WOL.

Free Access to WOL