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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 22, Number 7
BKCSDE 22(7)
July 20, 2001

Title	The Effect of Alkali Metal Ions on Reactions of 8-(5-Nitroquinolyl) 3-Furoate with Alkali Metal Ethoxides in Anhydrous Ethanol
Author	Ik-Hwan Um, Seung-Eun Lee, Ji-Sook Min
Keywords	Acyl-transfer reaction, Alkali metal ion catalysis, Ion pair, Kinetics.
Abstract	Pseudo-first-order rate constants have been measured spectrophotometrically for the reactions of 8-(5-nitroquinolyl) 3-furoate with alkali metal ethoxides in anhydrous ethanol. The plot of k_obs vs the concentration of alkali metal ethoxides is linear for the reactions performed in the presence of a complexing agent, 18-crown-6 ether, but exhibits upward curvatures for the corresponding reactions performed in the absence of the complexing agent, indicating that the alkali metal ions in this study behave as catalysts. Second-order rate constants were determined for the reactions with dissociated free ethoxide (k_EtO-) and with ion paired alkali metal ethoxides (k_{EtO-M +} ) from ion pairing treatments. The magnitude of catalytic effect (k_{EtO-M +} /k_EtO-) was found to be 1.7, 3.4 and 2.5 for the reaction of 8-(5-nitroquinolyl) 3-furoate, while 1.4, 3.6 and 4.2 for that of 4-nitrophenyl 2-furoate, 1.8, 3.7 and 2.4 for that of 8-(5-nitroquinolyl) benzoate, and 2.0, 9.8 and 9.3 for that of 8-(5-nitroquinolyl) 2-furoate with EtO^- Li⁺ , EtO^- Na⁺ and EtO^- K⁺ , respectively. A 5-membered chelation at the leaving group is suggested to be responsible for the catalytic effect shown by alkali metal ions.
Page	673 - 677
Full Text	PDF

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