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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 21, Number 8
BKCSDE 21(8)
August 20, 2000 

Total Synthesis of a New 7-Deoxyidarubicinone Derivative through the Functionalization of an A-Ring Side Chain
Young S. Rho, Hyun Kyoung Ko, Wan-Joong Kim, Dong Jin Yoo, Heun Soo Kang
A convenient total synthesis of a new 7-deoxyidarubicinone ivative21,the aglycon of the anticancer anti-biotic idarubicin analogue,is described.Keyfeatures of the synthesis are the Friedel-Crafts acylation and the functionalization of an A-ring side chain. A synthon 14 for the A and B rings was prepared from intermediate 6 in five steps.
774 - 778
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