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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 39, Number 9
JKCSEZ 39(9)
June 20, 1995 

 
Title
Synthesis and Antimicrobial Activity of Polymethacryloylsulfadiazine

Polymethacryloylsulfadiazine 의 합성과 항균활성
Author
Sun-Il Kim*, Jae-Won Na, Young-Jae Yun, Kyong-Rai Choi

김선일*, 나재운, 윤영재, 최경례
Keywords
Abstract
중합체약 polymethacryloylsulfadiazine의 합성은 DCC 법과 Acid Chloride법으로 비교 검토하고 그 중합체약에 대한 항균활성을 측정하였다. 중합체약은 Acid Chloride법에 의하여 높은 수득율(72%)로 합성할 수 있었으나, DCC법은 수득률(23%)이 낮았다. 중합체약의 항균활성 측정은 2단계 희석법에 의한 최소 발육 저지 농도로서 조사하였으며, Bacillus subtillis ATCC 6633. Mycrobacterium phlei IFO 3158, Micrococus luteus ATCC 9341, Salmonella typhimurium KCTC 1925, 및 Klebsiella pneumoniae KCTC 1560 균주들에 대해서는 강한 항균력을 보여주었다. 그러나, Staphylococcus aureus IFO 12732, Escherichia coli BE 1186, Escherichia coli AB 0111 및 Pseudomonas aeruginosa IFO 13130 균주들에 대해서는 유사한 항균력을 나타냈다. 한편 sulfadiazine 항균제가 진균류에 대하여 감수성을 보이지 않는 것처럼 중합체약에 있어서도 Candida albicans IFO 1594 균주는 항균력을 나타내지 않았다.

The synthetic procedures to synthesize polymethacryloylsulfadiazine were searched by DCC method and Acid Chloride mothod. Polymeric drug was synthesized by Acid Chloride method in high yield (72%) but DCC method in low yield (23%). The antimicrobial activities of polymeric drug were investigated in terms of minimum inhibitory concentrations by the common two-fold dilution technique. Polymeric drug revealed an excellent antimicrobial Bacillus subtillis ATCC 6633, Mycrobacterium phlei IFO 3158, Micrococus luteus ATCC 9341, Salmonella typhimurium KCTC 1925, Klebsiella pneumoniae KCTC 1560 and similar activity against Staphylococcus aureus IFO 12732, Escherichia coli BE 1186, Escherichia coli AB 0111, Pseudomonas aeruginosa IFO 13130. Polymeric drug have no antimicrobial activity against Candida albicans IFO 1594.

Page
749 - 754
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