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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 5, Number 3
BKCSDE 5(3)
March 20, 1984 

 
Title
Malyngolide Analogues. Synthesis of (±)-Dehydromalyngolide and (±)-Isomalyngolide
Author
Sunggak Kim, Youn Chul Kim, Chang Yong Hong
Keywords
Abstract
Two novel malyngolide analogues, (± )-dehydromalyngolide and (±)-isomalyngolide, of (-)-malyngolide antibiotic have been synthesized by application of our previously developed synthetic sequence for the synthesis of (± )-malyngolide. Dehydromalyngolide was synthesized from the known lactone (4) in a 55 % overall yield in six steps, while isomalyngolide was synthesized from the readily available keto ester (11) in a 56 % overall yield in four steps.
Page
97 - 100
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