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제110회 대한화학회 학술발표회, 총회 및 기기전시회 The Technology of the Chirality Conversion of Amino Acids

2012년 8월 31일 14시 52분 24초
IND2-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 14시 : 55분
공업화학 - Technology Transfer from University or Institute to Industry
저자 및
이화여자대학교 화학과, Korea

The binaphthol-based chiral receptor, 1, exhibits high efficiency in enantioselective recognition of 1,2-amino acids. The receptor is also a chirality conversion reagent (CCR), as it converts the L-form to D-form of amino acids and peptides. The compound 1 has the capability to form a Schiff base like PLP. In contrast to PLP, the compound 1 deracemizes the bound amino acids due to the chirality of the binaphthyl moiety. 그림 Extractive resolution coupled with racemization has been developed in order to realize economical conversion of L amino acids to D amino acids. This process includes the receptor 1, a phase transfer catalyst and a racemization catalyst. This technology is now applied in the industrial production of unnatural amino acids or nonproteinogenic amino acids, whose demands in both pharmaceutical industry and academic research are continuously increasing. References: 1. Kim, K. M.; Park, H.; Kim, H.-J.; Chin, J.; Nam, W. Org. Lett. 2005, 7, 3525. 2. Tang, L.; Choi, S.; Nandhakumar, R.; Park, H.; Chung, H.; Chin J.; Kim, K. M. J. Org. Chem. 2008, 73, 5996. 3. Park, H.; Kim, K. M.; Lee, A.; Ham, S.; Nam, W.; Chin, J. J. Am. Chem. Soc. 2007, 129, 1518. 4. Nandhakumar, R.; Ryu, J.; Park, H.; Tang, L.; Choi, S.; Kim, K. M. Tetrahedron, 2008, 64, 7704.