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A novel protein, Romo1, induces the oxidative DNA damage: Implication of Romo1 in development of anticancer drugs and antioxidants

2005년 9월 2일 13시 42분 15초
금14E6심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 16시 : 30분
의약화학 - 신약 발굴을 위한 화학유전체학 (Chemogenomics for Drug Discovery)
저자 및
유영도, 정영민, 유영아, 윤석준1, 김준석
고려대학교 의과대학 대학원 의학과,
1숙명여대 생물과학과,
The majority of endogenous reactive oxygen species (ROS) are produced in the mitochondrial respiratory chain, and an imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo1), which is localized in mitochondria. Romo1 was found to increase the level of ROS in the cells, and induce nuclear DNA damage. Increased Romo1 expression was observed in various cancer cell lines and tumor tissues. The exogenous expression of Romo1 augmented the transforming activity of the oncogenic H-Ras in an in vitro transformation experiment even though Romo1 itself does not show transforming activity. These results suggest that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can make some of them more malignant. Romo1 is a new promising target for the development of novel drugs aimed at cancer and other diseases.