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JKMC

ISSN 1017-2548
Volume 7, Number 2
JKCSEZ 7(2)
April 20, 1997

Title	Molecular Probes for the Binding Site of Inositol 1,4,5-trisphosphate (IP3) 3-Kinase and Comparison with IP3 Receptor
Author	Gildon Choi, Young-Tae Chang, Sung-Kee Chung, Kwan Yong Choi
Keywords
Abstract	Inositol 1,4,5-trisphosphate 3-kinase (IP3K) catalyzes the ATP-dependent phosphorylation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] generating inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. The inhibitory effects of all possible 38 regioisomers of inositol phosphates [InsPn] on the IP3K activity have been examined. The correlations between inhibitory potencies and their structural features have allowed an assessment of the environment at the bindingsite of IP3K and a proposed binding site model, which has been compared with the binding site model of IP3 receptor.
Page	106 - 114
Full Text	PDF

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