ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 40, Number 12
JKCSEZ 40(12)
December 20, 1996 

The relationship between chemical structure and antifungal activity of benzene ring substituents of 1-phenylpyrrolidine-2,5-diones is studied by testing of model compounds and use of conformational data. The analysis revealed a number of structural features as essential for the antifungal effect: (1) the presence of an intact-NCO group and benzene moiety; (2) the distance between para substituents and the N atom within the 5.318∼5.320 Å range; (3) the distance between substituent X3 and X5 in the interval 5.437∼6.072 Å for the active analogues. And other parameters were discussed.