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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 39, Number 11
JKCSEZ 39(11)
October 20, 1995 

Electrochemical Behaviors for Cathodic Reaction of N '-arly-N-alkyl-N-nitrosourea Drivatives

N '-aryl-N-alkyl-N-nitrosourea 유도체의 환원반응에 대한 전기화학적 거동
Mi Sook Won, Jack C. Kim, Euh Duck Jeong, Yoon-Bo Shim*

원미숙, 김정균, 정의덕, 심윤보*
유리질 탄소전극을 사용하여 조사한 몇가지 N '-aryl-N-alkyl-N-nitrosourea 유도체들의 전기화학적 환원반응은 확산지배적이고 비가역적인 반응이었다. 이들 유도체들의 환원 반응시의 교환속도 상수 k0값은 1.48×10-6∼5.32×10-7 cm/sec의 값을 나타내었다. Aryl기 및 alkyl기의 치환기에 따른 교환속도상수는 N '-aryl-N-alkyl-N-nitrosoureas 에서 aryl기가 phenyl일 경우, 다른 치환기보다 K0값이 1.3∼2.8배였다. N'-aryl-N-methyl-N-nitrosourea와 N '-aryl-N-(2-chloroethyl)-N-nitrosourea 유도체는 pH값이 높아짐에 따라 Ep값이 음전위쪽으로 이동하며 각 환원 반응에 참여한 H+ 의 수는 4~5개였다. 이 경우 aryl기의 치환기효과는 환원전위에 크게 영향을 미치지 않는 것으로 나타났다.

The electrochemical reduction reactions of N '-aryl-N-alkyl-N-nitrosourea derivatives with a glassy carbon electrode were diffusion controlled and irreversible. The exchange kinetic constant ko values for reduction reaction of the N '-aryl-N-alkyl-N-nitrosoureas were at the range of 1.48×10-6∼5.32×10-7 cm/sec. The k0 values for phenyl substituted on the aryl position were about 1.3∼2.8 times higher than that of other substituents. The same substituent for aryl groups on the both of N '-aryl-N-alkyl-N-nitrosourea and N '-aryl-N-(2-chloroethyl)-N-nitrosourea exhibited same value. The Ep value was shifted to the negative direction as pH increased. The number of protons participated to the reduction was 4∼5, respectively. The substituent effect of aryl group on the reduction potential was not observed in this case.

842 - 847
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