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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 39, Number 10
JKCSEZ 39(10)
August 20, 1995 

 
Title
Reduction of m-Bromonitrobenzene and Nitrosobenzene with Bakers' Yeast

Bakers' Yeast 를 이용한 m-Bromonitrobenzene 및 Nitrosobenzene 의 환원반응
Author
Kyungsoon Kim*, Woonphil Baik, Sunghwan Oh

김경순*, 백운필, 오성환
Keywords
Abstract
방향족 니트로 화합물을 선택적으로 환원시켜 치환제가 있는 아닐린을 생성하는 것은 산업적 측면에서 볼 때 의미있는 반응이다. 본 연구에서는 Bakers'Yeast-NaOH의 환원작용에 의하여 m-bromonitro-benzene의 니트로기가 선택적으로 빠르게 환원되어 치환체가 있는 아닐린 화합물이 형성됨을 확인하였고 특히 nitrosobenzene이 수산화 나트륨이 없는 조건에서 Bakers'Yeast만의 작용에 의해 환원되어 아닐린을 생성함을 확인하였다. 또한 nitrosobenzene의 Bakers'Yeast 환원에 미치는 저해제들의 효과 및 온도, pH의 영향 등을 조사하였다.

Rapid and selective reduction of aromatic nitro compounds is of important for the preparation of amino derivertives in organic synthesis, particularly when a molecule has other reducible substituents. While Bakers' Yeast has been used for the enantioselective reduction of carbonyl compounds, little attention has been paid to the reduction of aromatic nitro compounds with Bakers' Yeast. Nitro group of m-bromonitrobenzene was selectively and rapidly reduced to corresponding amino derivative in good yield by Bakers' Yeast in basic solution. Furthermore, nitrosobenzene was rapidly reduced to aniline in good yield by Bakers' Yeast under neutral condition. In this paper, we wish to report a rapid and simple reduction of m-bromonitrobenzene and nitrosobenzene to the corresponding amino derivatives using Bakers' Yeast. And the effects of various agents, temperature and pH on the reduction will be discussed.

Page
812 - 817
Full Text
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