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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 37, Number 9
JKCSEZ 37(9)
June 20, 1993 

Synthesis of N-Hydroxy-α-Amino Acid Esters

N-히드록시-α-아미노산 에스테르의 합성
Min Hyo Seo, Han Cheol Wang, Youn Young Lee, Yang Mo Goo

서민효, 왕한철, 이윤영, 구양모
N-Arylmethylideneglycine N-oxide alkyl esters(1)를 THF 용매내에서 lithium hexamethyldisilazide로 처리한 다음 할로겐화 알킬과 반응시켜 알킬화하고 이를 히드록실아민으로 분해시켜 N-hydroxy-α-amino acid esters(7)를 합성하였다.

N-Arylmethylideneglycine N-oxide alkyl esters(1) were alkylated with alkyl halides in THF using lithium hexamethyldisilazide as a base, followed by hydroxylaminolysis to give N-hydroxy-α-amino acid esters(7).

837 - 844
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