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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 36, Number 5
JKCSEZ 36(5)
October 20, 1992 
 
Title
 A Study on the Synthesis of New Medicinal Agents : Synthesis of 6-Thiocyanopenicillanic Acid Derivatives

새로운 의약품의 합성에 관한 연구 : 6-Thiocyanopenicillanic Acid 유도체의 합성
Author
 Young-Haeng Lee, Chai-Ho Lee, Won-Sik Choi

이영행, 이채호, 최원식
Keywords
Abstract
 6-aminopenicillanic acid의 diazo화 반응과 sodium thiocyanate와 반응으로 새로운 β-lactam 화합물인 6-thiocyanopenicillanic acid(1a)를 합성하고 p-nitrobenzyl bromide, chloromethylpivalate 및 1-chlorodiethylcarbonate들과의 반응에 의해 각각 해당되는 esters(1b∼d)를 합성하였다.

A new β-lactam compound, 6-thiocyanopenicillanic acid(1a) was prepared by the reaction of diazonium salt of 6-aminopenicillanic acid with sodium thiocyanate. Reaction of 6-thiocyanopenicillanic acid(1a) with p-nitrobenzyl bromide, chloromethylpivalate and 1-chlorodiethylcarbonate, respectively, afforded the corresponding esters(1b∼d).
Page
 760 - 763
Full Text
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