ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 34, Number 3
JKCSEZ 34(3)
June 20, 1990 

Antielastic fragment in GBⅠ-Ⅱ differ on P1 site with that of antitryptic fragment in LBI. To obtain further understanding of the role of amino acid residue near the reactive site, specificity of P1 site and loop size, Tyr substituted cyclic nonapeptide and cyclic pentapeptide were synthesized and the inhibition constants for some proteinases were calculated by Dixon method. Cyclic nonapeptide showed no inhibition for chymotrypsin but appeared low inhibitory activity for trypsin and elastase and that of cyclic pentapeptide possessed inhibitory activity for chymotrypsin.