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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 34, Number 2
JKCSEZ 34(2)
April 20, 1990 

 
Title
Studies on Synthesis of Block Copolymers Containing Polyester and Polypeptide for Drug Delivery System Ⅰ. Synthesis and Characterization of Copolymer of L-Lactic Acid and L-Glutamic Acid

폴리펩티드-의약 전달체 및 폴리펩티드 공중합체의 합성 및 물성에 관한 연구 (Ⅰ) L-Lactic Acid 와 L-Glutamic Acid 공중합체의 합성 및 그의 물성
Author
Hongbum Kim, Yong Kiel Sung, jaehee Jung, Hyunggee Baik, Tae Jin Min, Young Soon Kim

김홍범, 성용길, 정재희, 백형기, 민태진, 김영순
Keywords
Abstract
의약 전달체에 사용되는 생체분해성 고분자로서 L-lactic acid 와 L-glutamic acid가 각기 다른 조성비로 이루어진 공중합체를 합성하였다. Poly (L-lactide)는 zink oxide를 이용하여 합성하였으며, Poly (L-lactide) 말단에 3-Amino-l-propanol을 도입시킨 다음 이미 합성된 γ-benzyl-L-glutamate-N-carboxyanhydride (γ-BLG-NCA)를 개환중합시켜서 block copoly (L-lactide-γ-benzyl-L-glutamate)를 합성하였다. NMR로써 L-lactide와 γ-BLG-NCA가 서로 일정한 비율로 이루어진 공중합체가 합성되었음을 확인하였으며, 생성된 공중합체들의 열적성질은 시차주사열량계법 및 열무게 측정법으로 조사하였다.

As a possible biocompatible and biodegrable polymer skeleton for drug delivery system, block copolymers of L-lactic acid and L-glutamic acid with different composition were synthesized and characterized. Poly (L-lactide) was prepared by polymerization of L-lactide with zine oxide at 130℃ for 72 hrs. 3-Amino-l-propanol was introduced to poly (L-lactide) by an ester linkage in order to initiate polymerization. Polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride (γ-BLG-NCA) utiliizing the amino group of modified poly (L-lactide) as an initiator gave rise to the block copoly (L-lactide-γ-benzyl-L-glutamate). The NMR study of resulting block copolymers showed that the composition of L-lactic acid and γ-benzyl-L-glutamate in block copolymers was depended on the weight ratio of poly (L-lactide) and γ-BLG-NCA. The thermal properties of the resulting block copolymers were determined by the differential scanning calorimetry and by the thermogravimetry.

Page
203 - 210
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