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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 33, Number 2
JKCSEZ 33(2)
April 20, 1989 

 
Title
Synthesis of Optically Active 1-Aminoalkylphosphonic Acids

광학 활성을 갖는 1-Aminoalkylphosphonic Acid 의 합성
Author
Sung Ki Cho, Yong Joon Kim

조성기, 김용준
Keywords
Abstract
Diethylaminomethylphosphonate와 chiral 시약인 (S)-(-)-2-hydroxypinan-3-one으로부터 만든 Schiff염기를 알킬화하여 광학 활성을 갖는 (+)-1-aminoalkyphosphonic acid를 합성하였으며, (S)-(-)-2-hydroxypinan-3-one을 광학 분할제로 사용하여 만든 diethylaminomethylphosphonate의 Schiff염기로부터 관 크로마토그래피 방법으로 (±)-1-aminobenzylphosphonic acid를 광학분할하였다.

An efficient asymmetric synthesis of (+)-1-aminoalkyphosphonic acids is achieved by alkylation of Schiff base, prepared from diethylaminomethylphosphonate and (S)-(-)-2-hydroxypinan-3-one as a chiral reagent, and a new method of column chromatographic resolution of (±)-1-aminobenzylphosphonic acid via its Schiff base with (S)-(-)-2-hydroxypinan-3-one is described.

Page
257 - 262
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