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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 29, Number 5
JKCSEZ 29(5)
October 20, 1985 
 
Title
 A New Route to Diethyl 3,4,5-Trimethoxybenzylmalonate, a Trimethoprim Intermediate

Trimethoprim 중간체인 Diethyl 3,4,5-Trimethoxybenzylmalonate의 새로운 합성
Author
 Bong Young Chung, Chae Ho Lee

정봉영, 이채호
Keywords
Abstract
 3,4,5-trimethoxybenzoyl chloride와 diethyl malonate를 축합시킨 후, 염소화반응 및 가수소화 분해 반응을 거쳐 diethyl 3,4,5-trimethoxybenzylmalonate를 70%의 수득율로 합성하였다.

Direct condensation of 3,4,5-trimethoxybenzoyl chloride with diethyl malonate followed by chlorination and hydrogenolysis afforded diethyl 3,4,5-trimethoxybenzylmalonate in 70% overall yield.
Page
 539 - 542
Full Text
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