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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 29, Number 4
JKCSEZ 29(4)
August 20, 1985 

A Measure of Chemical Carcinogenic Activity for Metal Ions

금속이온에 대한 화학발암성의 척도
Byung-Kak Park, Hwhan-Jin Yeo

박병각, 여환진
금속이온이 생체내에서 생체성분과 금속착물을 형성하는 것이 여러가지 생물학적 작용의 첫단계로 인정되고 있다. 본 연구에서 금속이온의 착물형성에 중요한 인자로서 과잉편극세기가 순수한 친자성 척도가 됨을 알았으며, 또한 과잉편극세기가 금속착물의 생성상수와 관련된 Irving-Williams계열을 설명할 수 있었다. 실험적으로 발암성이 밝혀진 금속이온의 과잉편극세기의 값이 0.22이상이었으며 나아가서 과잉편극세기의 값이 0.22이상인 금속이온은 발암성을 가질 수 있을 것으로 예측된다. 따라서 이 양을 금속이온의 화학발암성의 척도로 채택할 것을 제안한다.

Formation of metal complex is the first step in the many biological actions of metal ions present in the biological systems. In this work the not electron affinity necessary for the formation of such metal complexes has been determined for a series of metal ions. It has been found that excess polarizing strength can be adopted as a measure of electron affinity and trend is the excess polarizing strength is related to Irving-Williams series. Those metal ions having greater than 0.22 in value of excess polarizing strength have been found to show carcinogenicity and other metal ions, which are supposed to be carcinogenic, have shows to have greater than 0. 22 in value of excess polarizing strength, demonstrating that excess polarizing strength could be used to determine if any metal ion possesses carcinogenic activity.

341 - 347
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