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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 27, Number 6
JKCSEZ 27(6)
December 20, 1983 

Opposite Effect of Spermine on the Susceptibility of Native and Denatured Calf Thymus DNA to DNase 1.

Native 및 Denatured Calf Thymus DNA의 DNase 1 에 대한 Susceptibility에 미치는 Spermine의 영향
Thong-Sung Ko, Joon Huh, Chun-Bae Lee, Moon-Kyeu Park

고동성, 허준, 이천배, 박문규
Spermine은 DNase 1에 대한 native 및 denatured calf thymus DNA의 susceptibility에 상반된 효과를 갖는다. spermine은 그 native DNA의 susceptibility를 증가시키지만 그 denatured DNA의 것은 감소 시킨다. spermine이 존재하지 않을 경우에는 그 deoxyribonuclease의 반응성은 native 및 denatured DNA의 conformation차이에 외견상 무감각한 것으로 나타난다.

Spermine has opposite effect on the susceptibility of native and denatured calf thymus DNA toward deoxyribonuclease Ⅰ (DNase I; deoxyribonucleate 5'-oligonucleotidohydrolase; EC; from bovine pancreas). It enhances the susceptibility of the native DNA, whereas depresses that of the denatured DNA. In the absence of spermine, the reactivity of the deoxyribonuclease is apparently insensitive to the conformational difference of the native and denatured DNA.

429 - 433
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