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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 25, Number 3
JKCSEZ 25(3)
June 20, 1981 

 
Title
Synthesis and Antimicrobial Properties of Surfactants Containing Phenazine Ring (Ⅰ)

Phenazine Ring을 가진 계면활성제의 합성과 그 항균성 (제1보)
Author
Jong Dae Kim, Yeong Hoon Park

김종대, 박영훈
Keywords
Abstract
Aniline과 alcohol류에서 4-aminoalkylbenzene을 합성하여, 이것을 아세틸화, 니트로화, 가수분해하여 3-nitro-4-aminoalkylbenzene을 얻고 아미노기 이탈반응을 통해 3-nitroalkylbenzene을 합성하여 anthranilic acid와 반응시켜 7-alkyl-1-carboxyphenazine 유도체를 합성하였다. 생성물은 원소분석, IR, NMR 스펙트럼으로 확인하였다. 이들 유도체들의 수용액에 대한 표면장력을 측정하였고, 아울러 Gram 양성균, Gram 음성균, 진성균에 대한 항균성을 조사하였다. 시험결과 alkyl기가 치환된 phenazine 유도체의 항균성은 alkyl기가 없는 1-carboxyphenazine 보다 강한 것으로 나타났다.

7-Alkyl-1-carboxyphenazine derivatives, bearing butyl or octyl group, were synthesize by the reaction of anthranilic acid with 3-nitroalkylbenzene, prepared from aniline and alcohols as starting materials through alkylation of 3-nitro-4-aminoalkylbenzene. And the products were also identified by elementary analysis, IR and NMR spectra. Surface tension of these derivatives in aqueous solution was determined. And also Antibiotic activity of these derivatives was tested, using Gram positive and negative bacillus and fungi. It showed that the antibiotic activity of these alkyl-substituted 1-carboxyphenazine derivatives was stronger than that of the 1-carboxyphenazine.

Page
199 - 205
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