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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 19, Number 5
JKCSEZ 19(5)
October 20, 1975 

Selective Reduction of Keto Esters with Zinc Borohydride

수소화붕소 아연에 의한 케토에스데르의 선택환원
Nung Min Yoon, Jahyo Kang

윤능민, 강재효
대표적 케토에스테르를 수소화붕소아연으로 선택환원하여 해당하는 히드록시에스테르 또는 락톤을 좋은 수득률로 합성하였다.

Selective reduction of carbonyl group with zinc borohydride in the presence of ester functional group was demonstrated with seven representative keto esters. Either hydroxy esters or lactones were obtained in good yields; ethyl 6-hydroxyheptanoate (83.0 %), ethyl 2,6-dimethyl-4-hydroxy-2-cyclohexenecarboxylate (82.3 %), ethyl p-(α-hydroxyethyl)-phenylacetate (78.9 %), 4-phenylbutyrolactone (70.2 %), and 3-phenylphthalide (92.4 %) were obtained from the corresponding keto esters.

360 - 366
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