Current time in Korea 14:09 Oct 25 (Sun) Year 2020 KCS KCS Publications
KCS Publications
My Journal  Log In  Register
HOME > Search > Browsing(JKCS) > Archives

Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 19, Number 2
JKCSEZ 19(2)
April 20, 1975 

Synthesis of Dipeptides Containing Aminoalkylphosphonic Acid

Aminoalkylphosphonic Acid를 가지는 Dipeptide의 합성
Suk In Hong, Man Khyun Rho, Yong Joon Kim

홍석인, 노만균, 김용준
1-Aminoalkylphosphonic acid인 DL-1-aminoethylphosphonic acid(1-AEP)와 DL-1-aminopropylphosphonic acid(1-APP)를 아미노산인 glycine, DL-alanine, DL-phenylalanine과 염기성 수용액 상에서 반응시켜 아직까지 발표되지 않은 다음의 dipeptide 들을 합성하였다. N-Phthalylglycyl-1-AEP, N-phthalyl-dl-alanyl-1-AEP, N-phthalyl-dl-phenylalanyl-1-AEP, N-phthalylglycyl-1-APP, N-tosylglycyl-1-App 및 N-tosyl-dl-alanyl-1-AEP 위의 화합물들은 모두 흰색의 고체로 얻어졌으며 ninhydrine test, IR spectra, 전위차적정, 원소분석에 의해 확인되었다.

DL-1-aminoethylphosphonic acid(1-AEP) and DL-1-aminopropylphosphonic acid(1-APP) were synthesized from the propionic acid and butyric acid respectively using the modified cutius degradation. The following unreported derivatives containing peptide linkage were synthesized: N-phthalylglycyl-1-AEP, N-phthalyl-dl-alanyl-1-AEP, N-phthalyl-dl-phenylalanyl-1-AEP, N-phthalylglycyl-1-APP, N-tosylglycyl-1-AEP and N-tosyl-dl-alanyl-1-AEP These compounds were characterized and identified by means of elemental analysis, potentiometric titration, infrared spectroscopy and ninhydrin test.

134 - 141
Full Text