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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 12, Number 1
JKCSEZ 12(1)
February 20, 1968 

Radio iodination of various aromatic derivatives in organic solvent at low temperature

방사성 요오드화 반응 (제 Ⅱ 보) 유기용매 중에서의 각종 방향유도체의 저온 요오드화 반응
You Sun Kim, Chong Doo Kim

김유선, 김종두
Radio iodination of various aromatic derivatives (aniline, toluene, iodobenzene, acetanilide, benzene, benzoic acid) were achieved at low temperature by a chloroamine-T procedures in presence of polar solvent(dioxane). Organic base (piperidine) was used as the catalyst. Iodine replacement reaction had occured on the aromatic or alicyclic ring by this reaction, and the kind and ratio of iodinated products were proved to be different from those of usual iodide reaction in organic solvent at low temperature. The reactivity of various aromatic or alicyclic compounds towards the present iodination system was evaluated and the scope and limitation of the present procedures in the preparation of radio pharmaceuticals were discussed.
35 - 38
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