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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 11, Number 2
JKCSEZ 11(2)
April 20, 1967 

 
Title
Radio Iodination of Organic Compounds (1) A Low Temperature Procedures

방사성 옥화반응 (제1보) 저온옥화반응
Author
YOU SUN KIM, CHONG DOO KIM

김유선, 김종두
Keywords
Abstract
방사성 沃화반응 중 분해하기 쉬운 화합물의 옥화반응으로 유용한 저온옥화반응에 관하여 연구하였다. Chloroamine-T를 이용한 옥화반응은 저온에서 높은 수율로 방사성 옥화반응을 진행시킬 수 있었으며, 활성화된 방향핵이 있는 또는 이에 유사한 아미노산, 단밸질화합물, 각 중 Phenol류의 옥화가 불가능하였으나 2중결합화합물 및 일반화합물엔 큰 효과가 없었다. 반응수율은 100~60%이었으며, 각 화합물의 시약에 대한 반응도는 친전자반응에 대한 방향핵의 반응도와 비례하는 것이었다. 반응조작을 기술하였으며 반응과정을 고찰하였다.

A procedure, which is effective enough to label various compounds at low temperature by radioactive iodine, was investigated. The chloramine-T procedure was mostly effective for labelling various protein, amino acids, hormones, and organic compounds by iodine, and the procedure was able to afford both high specific activity and high radiochemical yield. However, the procedure was ineffective for labelling unsaturated compounds or other organic compounds which has not active aromatic nucleus of reactive character. The radiochemical yield of the procedure was generally averaged from 100% to 60%. The reactivity of the aromatic part of the organic compound towards this reagent was correspond to that of an electrophillic reagent. The procedures were described and the reaction path was considered.

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