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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 10, Number 2
JKCSEZ 10(2)
April 20, 1966 

Reaction of Nitrous Acid on 5-Aminopyrimidines [Ⅲ] Sandmeyer Reaction of Diazotizated 5-Amino-6-Methyluracil

Aminopyrimidine 유도체에 대한 아질산의 작용 [Ⅲ] Diazotizated 5-Amino-6-Methyluracil에 대한 Sandmeyer 반응
Sae Hee Chang, Bo-Sup Hahn, In Kyu Kim, Sae Hwa Oh

장세희, 한보섭, 김인규, 오세화
Sandmeyer 반응으로 5-Amino-6-methyluracil로 부터 5-iodo-, 5-chloro- 및 5-bromo-6-methyluracil을 간편하게 합성하는 방법을 새로히 마련하였다. 이 방법에 따르면 5-halo-6-methyluracil이 70% 이상의 좋은 수득률로 얻어지며 부반응을 수반하지 않으므로 새성물이 정제가 쉽고 편리하게 5-halouracil을 얻을 수 있다는 이점이 있다.

A new conventional method for the preparation of 5-iodo, chloro-, and bromo-6-methyluracil by Sandmeyer reaction was described. According to this procedure, 5-halo-6-methyluracils have been prepared in high yields (up to 70%) without any difficulties to obtain highly pure products. No appreciable competing reaction was observed.

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