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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 8, Number 2
April 20, 1964 

Synthesis of 5-bromouracil-Br82by Isotopic Exchange Method

Isotopic Exchange 에 의한 5-bromouracil-Br82의 합성
Hyung Chick Pyun, Jae Rock Kim

변형식, 김재록
As the bromination method with Br282 for the synthesis of 5-bromouracil-Br82 gave products with considerable impurities, e. g. uracil etc. an attempt to produce pure one by isotopic exchange method was performed. Bromide-82 ion such as NH4Br82 or HBr82 undergoes no isotopic exchange with 5-bromouracil-Br. However, isotopic exchange between NH4Br82 and Br2, and between Br282 and 5-bromouracil-Br were too fast to determine the rate. The result indicated that this method can be used in the production of pure 5-bromouracil-Br82. It was also found that the use of reducing agent to maintain Br82 as bromide form was unnecessary on NH4Br82 production from reactor.
39 - 42
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