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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 63, Number 6
JKCSEZ 63(6)
December 20, 2019 

 
Title
A Facile Solvent and Catalyst Free Synthesis of New Dihydro Pyrimidinones as Antimicrobial Agents
Author
Hemant Hegde, Chuljin Ahn, Santosh L Gaonkar, Nitinkumar S Shetty*
Keywords
Dihydropyrimidinones, One-pot synthesis, PEG-400, Microwave synthesis
Abstract
An efficient one pot multicomponent synthesis of pyrimidinone derivatives of Biginelli type is described. 4- amino-6-aryl-pyrimidine-5-carbonitrile molecules were synthesized efficiently via three-component Biginelli-type condensation of aldehyde, malononitrile, and semicarbazone as urea substituent in the presence of a catalytic amount of PEG-400 as green medium under microwave irradiation. The reactions proceeded efficiently in the presence of microwave radiation to afford the desired products in good to excellent yields. Products have been confirmed by IR, and NMR spectral analysis. All the molecules were tested for their antimicrobial activity against E. coli, S. aureus, P. aeruginosa and C. tropicalis. Some of the compounds have shown moderate to good inhibition efficiency against both gram-positive and gram-negative bacteria. The potent activity was observed against the fungal species with minimum inhibition concentration 12.5 µg/mL.
Page
435 - 445
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