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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 63, Number 2
JKCSEZ 63(2)
April 20, 2019 

 
Title
Chalcones-Sulphonamide Hybrids: Synthesis, Characterization and Anticancer Evaluation
Author
Mahammadali Khanusiya*, Zakirhusen Gadhawala
Keywords
Chalcones-sulphonamide hybrid, Anticancer, Cell Lines, Cytotoxicity
Abstract
A panel of chalcone-sulphonamide hybrids has been designed by tethering appropriate sulphonamide scaffold with substituted chalcones as a multi-target drug for anticancer screening. Chalcones were prepared by Claisen-Schmidt condensation reaction of a substituted aldehyde with para aminoacetophenone. All the synthesized compounds were evaluated against selected five cancer cell lines, MCF-7 (Breast cancer), DU-145 (Human prostate Carcinoma), HCT-15 (Colon cancer), NCIH-522 (stage 2, adenocarcinoma; non-small cell lung cancer) and HT-3 (Human cervical cancer). Most of the synthesized chalcone-sulphonamide hybrids showed amended cytotoxic activity against various cancer cell lines which may be attributed to the linkage of sulphonamide with chalcone skeleton. The synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR and HR-LCMS and spectral study assert the structures of synthesized sulphonamide-chalcone hybrids.
Page
85 - 93
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