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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 62, Number 1
JKCSEZ 62(1)
February 20, 2018

Title	Synthesis of Rhamnazin and Ombuin as Methylated Metabolites of Quercetin 케르세틴의 메틸화된 대사체인 람나진과 옴부인의 합성
Author	Jongyun Jang, Dong Wook Kang* 장종윤, 강동욱*
Keywords	람나진, 옴부인, 케르세틴, 메틸화 , Rhamnazin, Ombuin, Quercetin, Methylation
Abstract	케르세틴의 메틸화된 대사체인 람나진과 옴부인은 항암제와 항염증제로서의 개발 가능성이 높은 물질이다. 본 연구에 서는 케르세틴 수산기의 선택적인 메틸화를 통하여 기존의 합성법이 알려지지 않은 람나진의 합성법을 개발하였다. 그리고 케 르세틴의 메틸화된 대사체 중의 하나인 옴부인의 기존 합성법의 문제점을 수정한 새로운 합성법을 제시하였다. The methylated metabolites of quercetin, rhamnazin and ombuin are highly likely to develop as anticancer and anti-inflammatory agents. In this study, we synthesized rhamnazin through selective methylation of quercetin hydroxyl group, which has not been reported so far. In addition, a new synthetic method was developed to correct the problems of previous synthetic method of ombuin, one of the methylated metabolites of quercetin.
Page	19 - 23
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