ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 59, Number 5
JKCSEZ 59(5)
October 20, 2015 

The solvolysis rate constants of di-n-butyl phosphorochloridate ((CH3CH2CH2CH2O)2POCl, 1) in 28 different solvents are well correlated with the extended Grunwald-Winstein equation, using the NT solvent nucleophilicity scale and YCl solvent ionizing scale, with the sensitivities values of 1.40 and 0.42 for l and m, respectively. These l and m values can be considered to support an SN2 reaction pathway. This interpretation is further supported by the activation parameters, i.e., relatively small positive ΔH≠ (8.0 to 15.9 kcal·mol−1) values and large negative ΔS≠ (−25.8 to −53.1 cal·mol−1·K−1) values, the Kivinen’s n values (0.9~1.7), and the solvent kinetic isotope effect (1.62).