Current time in Korea 06:58 Dec 02 (Wed) Year 2020 KCS KCS Publications
KCS Publications
My Journal  Log In  Register
HOME > Search > Browsing(JKCS) > Archives

Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 59, Number 1
JKCSEZ 59(1)
February 20, 2015 

 
Title
Diastereoselective Reduction of 2,3-Dioxo-4-carboxy-5-substituted Pyrrolidines Using NaBH4/AcOH and Heterogenous Hydrogenation Reactions
Author
Mohd Fazli Mohammat, Nurul Shulehaf Mansor, Zurina Shaameri, Ahmad Sazali Hamzah*
Keywords
2,3-Dioxo-pyrrolidine, Diastereoselective, Enol reduction
Abstract
Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidine 1 by NaBH4/AcOH and heterogenous hydrogenation were reported. Stereochemical assignment and diastereomeric ratios of the products were determined using 1H NMR and single crystal X-ray analyses. The steric factors of the C-5 substituents of the pyrrolidinone was shown to have an interesting influence on both the yield and diastereoselectivity of the reduced product.
Page
31 - 35
Full Text
PDF