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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 58, Number 2
JKCSEZ 58(2)
April 20, 2014 

Efficient Synthesis of Novel 3-Substituted Coumarin-3-carboxamide
Enayatollah Sheikhhosseini, Saeed Balalaie*, Mohammad Ali Bigdeli, Azizollah Habibi, Hamed Piri Moghaddam
3-Substituted amidated coumarins, Ugi-4CR, Pseudopeptides, Fluoresence property
A series of novel pseudopeptides contained coumarin skeleton were synthesized through the Ugi-four-component reaction. The 3-substituted coumarin-3-carboxamides were formed through reaction of benzaldehyde derivatives, anilines, coumarin-3- carboxylic acid and isocyanides with high yields and high bond-forming efficiency at room temperature. These novel amidated coumarins exhibit brilliant fluorescence in range of 535−547 nm in chloroform.
186 - 192
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