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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 58, Number 1
JKCSEZ 58(1)
February 20, 2014 

Synthesis and in Vitro Antimicrobial Evaluation of Benzothiazole Incorporated Thiazolidin-4-ones Derivatives
Shikha Agarwal*, Dinesh Kumar Agarwal, Naveen Gautam, Kshamta Agarwal, Dinesh Chandra Gautam
Benzothiazole, Thiazolidin-4-ones, N-(5,7-dimethylbenzo[d]thiazol-2-yl)hydrazine carboxamide, Antimicrobial activity
In the course of work on new pharmacologically active antimicrobial agents, we have reported the synthesis of a new class of structurally novel derivatives, incorporating two bioactive structures, a benzothiazole and thiazolidin-4-one, to yield a class of compounds having interesting antimicrobial properties. The antimicrobial properties of the synthesized compounds were investigated against bacteria (Staphylococcus aureus and Escherchia coli) and fungi (Candida albicans and Aspergillus niger) using serial plate dilution method. The structure of the synthesized compounds have been established by elemental analysis and spectroscopic data.
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