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ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 57, Number 5
JKCSEZ 57(5)
October 20, 2013 |
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Title |
Preparation of Gold Coated Liposomes for CT Contrast Medium
CT 조영을 위한 금 코팅 리포솜의 제조
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Author |
Tae In Wee, Ye Won Jeon, Young Jae Cho, Sung Keun Cho, Jeung Ha, Jeong Won Lee, Sun Hang Cho, Hee Dong Han*, Byung Cheol Shin*
위태인, 전예원, 조영재, 조성근, 하 정, 이정원, 조선행, 한희동*, 신병철* |
Keywords |
Gold, Liposomes, Contrast medium, CT
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Abstract |
The use of medical imaging has been increased for diagnosis of cancer or vessel disease. Among the medical imaging, computed tomography (CT) is one of the popular methods, however, which should need administration of contrast medium. Therefore, we developed gold coated liposomes (GCL) as a contrast medium. To coat gold on the liposomal surface, positive charged liposomes was prepared and then negative Au- can coat on the liposomal surface by electronic interaction. The size of GCL was 154.8 ± 9.2 nm and surface charge was 27 ± 3.2 mV, respectively. The morphology of GCL was confirmed by electron microscopy (SEM) and transmission electron microscopy (TEM). The coating efficiency of gold was 18%. Chemical procedure for gold coating on liposomal surface was not toxic for cell cytotoxicity by MTT assay. Finally, we demonstrated attractive CT image for GCL. Taken together, the GCL would be useful for various vessel related disease as a contrast medium.
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634 - 639 |
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