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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 57, Number 4
JKCSEZ 57(4)
August 20, 2013 

Ultrasound-Triggered Drug Release of Hydroxyapatite Coated Liposomes

하이드록시아파타이트 코팅 리포솜의 초음파에 의한 약물방출
Sung Keun Cho, Tae In Wee, Jeung Ha, Sun Hang Cho, Kun Han, Hee Dong Han*, Byung Cheol Shin*

조성근, 위태인, 하 정, 조선행, 한 건, 한희동*, 신병철*
Hydroxyapatite, Liposome, Ultrasound, Drug release, Stability
Liposomes, which can deliver payload at target site, have been studied as drug carrier. However, conventional liposomes have limitation for drug release at target site. Therefore, we developed hydroxyapatite (HA) coated ultrasound sensitive liposomes to increase drug release at target site and to enhance stability in blood stream. Control liposome was prepared using hydrogenated soy phosphatidylcholine (HSPC) and cholesterol, and then we assessed HA coating on the surface of control liposomes using calcium acetate, phosphoric acid, and 25% ammonium solution. Doxorubicin was used as a model drug. Size of HA coated liposomes was 120 nm and encapsulation efficiency of doxorubicin in liposomes was up to 95%. Size of HA coated liposomes are not changed in 30% serum solution, however, the control liposomes was 1.4 fold increased. After ultrasound triggered drug release from liposomes, intracellular efficiency of drug released from HA coated liposomes was 3 fold increased compared to control liposomes. In this study, we developed ultrasound sensitive liposomes to enhance drug release, which will be applied in controlled drug release at disease site.
493 - 498
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