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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 57, Number 2
JKCSEZ 57(2)
April 20, 2013 

Design, Synthesis and Antibacterial Activity Studies of Novel Quinoline Carboxamide Derivatives
Yellappa Shivaraj, Malenahalli H Naveen, Giriyapura R Vijayakumar*, Doyijode B Aruna Kumar
Quinoline-6-carboxamides, 2-Chloro quinoline-4-carboxamides, Antibacterial activity
A series of novel quinoline-6-carboxamides and 2-chloroquinoline-4-carboxamides were synthesized by the reaction of their analogous carboxylic acids with various amine derivatives in the presence of base TEA and protecting agent BOP at room temperature. Synthesized compounds were confirmed by spectral characterization viz IR, 1H-NMR, and MS. Antibacterial activity carried out against Escherichia coli and Staphyllococcus aureus indicated that the synthesized compounds were active against these microorganisms.
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