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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 56, Number 3
JKCSEZ 56(3)
June 20, 2012 

Synthesis and Biological Studies of Novel Biphenyl-3,5-dihydro-2Hthiazolopyrimidines Derivatives
S Maddila, G L V Damu, E O Oseghe, O A Abafe, C Venakata Rao, P Lavanya*
Biphenyl-3,5-dihydro-2H-thiazolopyrimidines derivatives, Antioxidant activity, Antibacterial, Antifungal activities
A new series of ethyl 2-(4-substitutedbenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5- dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives (8a-j) were synthesized. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, LCMS mass and C, H, N analyses. All newly synthesized compounds were screened for their In vitro antioxidant activity (Scavenging of hydrogen peroxide, Scavenging of nitric oxide radical, and Lipid peroxidation inhibitory activity), antibacterial (Escheria coli, Pseudonmonas aeruginosa (gram-negative bacteria), Bacillus subtillis, Staphylococcus aureus (gram-positive bacteria)) and antifungal (Candida albicans Aspergillus niger) studies.
334 - 340
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