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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 56, Number 2
JKCSEZ 56(2)
April 20, 2012 

Synthesis and Antidiabetic Evaluation of Benzothiazole Derivatives
Mariappan G, Prabhat P, Sutharson L, Banerjee J, Patangia U, Nath S
Benzothiazole, Hypoglycemic activity, Riluzole, Antitumor activity, Diabetes
A novel series of benzothiazole derivatives were synthesized and assayed in vivo to investigate their hypoglycemic activity by streptozotocin-induced diebetic model in rat. These derivatives showed considerable biological efficacy when compared to glibenclamide, a potent and well known antidiabetic agent as a reference drug. All the compounds were effective, amongst them 3d showed more prominent activity at 100 mg/kg p.o. The experimental results are statistically significant at p<0.01 and p<0.05 level.
251 - 256
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