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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 6
JKCSEZ 55(6)
December 20, 2011 

 
Title
Synthesis and Characterization of Lactobionic Acid Grafted Phenylalanyl-Glycyl-Chitosan
Author
He Ping Li*, Shan Li, Zhou Dong Wang, Long Qin
Keywords
Grafted chitosan, Drug carrier, prepare, Lactobionic acid
Abstract
In order to enhance the target action of chitosan-based drug, this paper firstly prepared phenylalanyl-glycylchitosan (Phe-Gly-CS) by grafting the key intermediate, bromoacetyl-phenylalanine (BA-Phe) onto chitosan. Then the target sugar molecule, lactobionic acid (LA), was grafted to Phe-Gly-CS and the topic compound lactobionic acid grafted phenylalanyl- glycyl-chitosan (Phe-Gly-CS-LA) was finally obtained in a yield of 78.8%. The product were characterized by FTIR, MS and 1H NMR. The preparing condition of BA-Phe was optimized as follows: the best pH was 10-11, the optimum temperature was -4 oC, the reaction time was 1.5 h.
Page
978 - 982
Full Text
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