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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 6
JKCSEZ 55(6)
December 20, 2011 

 
Title
Synthesis and Cytotoxicity Evaluation of Phosphorylated Derivatives of Ribavirin
Author
Valasani Koteswara Rao, Sanapalli Subba Reddy, Kilaru Raveendra Babu, Kuntrapakam Hema Kumar, Sunil Kumar Ghosh, Chamarthi Naga Raju*
Keywords
Phosphorylated ribavirins, Trypan blue assay, MTT assay, MCF-7 cell lines
Abstract
Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, 1H, 13C, 31P NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines.
Page
952 - 959
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