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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 6
JKCSEZ 55(6)
December 20, 2011

Title	Microwave-Assisted One-Pot Synthesis of Octahydroquinazolinone Derivatives Catalyzed by Thiamine Hydrochloride Under Solvent-free Condition
Author	Pravin V Badadhe, Asha V Chate, Dattatraya G Hingane, Pravin S Mahajan, Namdev M Chavhan, Charansingh H Gill*
Keywords	Thiamine hydrochloride, Biginelli reaction, Octahydroquinazolinone derivatives, Microwave-irradiation, Solvent-free
Abstract	Thiamine hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of thiamine hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
Page	936 - 939
Full Text	PDF

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